RetinaDigest

The Cincinnati Methotrexate Protocol—comprising an intraoperative intravitreal infusion plus four postoperative injections—significantly improved single surgery success rates, reduced postoperative PVR, and yielded superior visual acuity compared to controls in complex PVR grade C retinal detachment repair.

In patients with symptomatic ERM and good baseline visual acuity (20/40 or better), PPV with ERM peel is safe and effective, with 80% maintaining or improving vision and 92% reporting symptomatic improvement.

This theoretical model proposes that endogenous electric fields (EEFs), generated by ionic fluxes across Müller cells and the RPE, guide electrotaxis-driven glial cell migration to facilitate macular hole closure, offering a unifying biological explanation for the success of diverse surgical techniques.

Serum Ang-1, sFLT-1, and sST2 levels—individually and as ratios—distinguished anti-VEGF responders from non-responders in DME patients, with AUC values of 0.9, suggesting their potential as early biomarkers of treatment response.

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This retrospective OCTA study of 27 MacTel type 2 patients demonstrated significant macular thinning across all inner ETDRS subfields and reduced deep capillary plexus vessel tortuosity, with both parameters serving as independent predictors of MacTel type 2 on multivariate analysis.

This case report describes an 18-month multimodal imaging follow-up of hyperacute outer retinal dysfunction (HORD) in a 3-year-old girl, demonstrating partial central ellipsoid zone recovery with immunosuppressive therapy and novel observation of peripheral blotchy pigmentation at presentation.

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In HIV-infected patients, CD4 T-cell count demonstrated superior discriminatory performance over CD4/CD8 ratio for identifying HIV-related posterior segment disease, with a threshold of ≤100 cells/μL yielding 92.3% sensitivity and 75.0% specificity.

This retrospective case series characterizes four distinct OCT morphologic patterns of sarcoid retinal granulomas using multimodal imaging, suggesting these lesions are an underrecognized manifestation of ocular sarcoidosis that can aid in differential diagnosis of retinal infiltrative lesions.

In a cross-sectional analysis of 2,127 adults with noninfectious uveitis from the All of Us Research Program, structural social determinants of health—including food insecurity, transportation difficulty, limited health literacy, and low educational attainment—were significantly associated with reduced eye care utilization, while psychosocial adversity was not.

This case series describes a distinctive atypical presentation of ocular toxoplasmosis termed 'acute inner foveal toxoplasmic maculopathy,' characterized by focal inner retinal cavitation, ellipsoid zone disruption, and outer nuclear layer involvement on SD-OCT, with limited intraocular inflammation and favorable anatomical response to treatment.

In this multicenter prospective cohort of 1,537 uveal melanoma patients, 15-GEP/PRAME classification retained independent prognostic validity for metastatic risk regardless of whether confirmatory cytopathology was available, supporting its use in guiding surveillance even when tissue diagnosis is not obtained.

In the largest and longest follow-up study of 103Pd plaque brachytherapy for choroidal melanoma, 170 patients achieved 100% local tumor control over a minimum 10-year period, with visual acuity retention of 20/200 or better maintained in 87% at 15 years and 63.7% at 20 years.

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This case report describes a rare occurrence of diffuse posterior scleritis following uneventful small-incision cataract surgery in a systemically healthy 55-year-old woman, successfully treated with IV pulse methylprednisolone, though residual foveal ellipsoid zone disruption limited final visual recovery to 6/12.

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Abstract not available — see full article for details.