RetinaDigest

This systematic review and meta-analysis of 14 studies (1,585 eyes) found no statistically significant difference in anatomical closure or visual acuity between fluorinated gas and room air tamponade after macular hole surgery, though evidence certainty was very low throughout.

This meta-analysis of 11 studies found that adjunctive scleral buckling (SB) with PPV for giant retinal tear-associated retinal detachments did not improve overall single-surgery anatomic success, final anatomic success, or final visual acuity compared to PPV alone, though a subgroup analysis suggested a potential benefit of PPV+SB in younger patients (mean age <40 years).

Abstract not available — see full article for details.

Abstract not available — see full article for details.

A global modelling study estimated AMD prevalence at 10.03% in 2021 using the standardized Beckman classification across 204 countries, projecting continued increases through 2050 while identifying tobacco reduction and increased physical activity as modifiable risk factors that could meaningfully reduce disease burden.

In this multicenter retrospective study of 53 eyes with angioid streak-associated subretinal fluid, long-term visual and structural outcomes were comparable between neovascular (70%) and non-neovascular (30%) phenotypes, underscoring that SRF alone should not be interpreted as evidence of CNV activity.

Greater quantitative reticular pseudodrusen (RPD) burden—measured by automated deep learning assessment of en face area and volume—is independently associated with impaired rod-mediated dark adaptation and predicts faster functional decline over time in non-advanced AMD, supporting its role as a prognostic structural biomarker.

In this prospective cohort study of PCV eyes achieving complete polypoidal regression after aflibercept, approximately half remained quiescent on PRN management over 2 years, while the other half recurred—with 21% losing 10 or more letters and 36% developing new hemorrhage at recurrence.

The first-in-human autologous iPSC-derived RPE sheet transplantation demonstrated sustained graft survival and structural stability at 10-year follow-up in a single patient with neovascular AMD, providing long-term safety evidence for iPSC-based retinal cell therapy.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

A 12-year-old girl presented with bilateral vaso-occlusive retinopathy as the initial manifestation of primary antiphospholipid syndrome (APS), highlighting the importance of antiphospholipid antibody testing in pediatric patients with unexplained retinal vascular occlusive disease.

A TriNetX database study of over 30 million U.S. children found that non-infectious pediatric uveitis incidence and prevalence rose significantly from 2016 to 2025, with anterior uveitis predominating but intermediate and posterior subtypes carrying the greatest ocular morbidity and vision loss.

A 13-month-old infant developed bilateral retinitis, retinal vasculitis, and exudative retinal detachment two weeks after MMRV vaccination, with positive measles serology but negative PCR, ultimately resulting in stable bilateral macular scars and final visual acuity of 6/9 OU over a six-year follow-up.

This case report describes a 19-year-old female with acute outer retinopathy (AOR) whose OCT demonstrated the ASHH sign—indicating complete photoreceptor disruption—before significant fundus changes were visible, underscoring OCT's critical role in early diagnosis of this aggressive AZOOR-spectrum entity.

Abstract not available — see full article for details.

This systematic review and meta-analysis of seven studies found that systemic JAK inhibitors demonstrate a consistent favorable direction in refractory non-infectious intraocular inflammation, with filgotinib showing the strongest placebo-controlled evidence, though extreme heterogeneity and very low certainty evidence limit definitive conclusions.

In a retrospective series of 60 patients with refractory non-infectious uveitis (NIU) at a South Indian tertiary centre, biologic therapy—predominantly adalimumab—achieved significant intraocular inflammation control with stable visual acuity and a favorable safety profile across pediatric and adult populations.

This Korean post-marketing surveillance study demonstrated that adalimumab (Humira) is safe and potentially effective in real-world patients with non-infectious intermediate, posterior, or panuveitis, with significant improvements in anterior chamber inflammation and vitreous haze at 22 weeks and no serious drug-related adverse events.

Atypical ocular toxoplasmosis frequently masquerades as ARN or CMV retinitis, causing a mean diagnostic delay of 26.4 days during which ineffective empiric antivirals are administered, resulting in poor visual outcomes with over half of affected eyes retaining final visual acuity worse than 20/200.

This review synthesizes multimodal imaging, molecular profiling, and in vitro data to elucidate the pathogenic mechanisms driving retinal inflammation in ocular syphilis, highlighting the central roles of monocytes/macrophages, pro-inflammatory cytokines, and Treponema pallidum-mediated disruption of blood-retinal barriers.

In a single-center retrospective study, metastatic cancer patients who developed ICI-associated uveitis demonstrated significantly better cancer response rates (75% vs 50%, p=0.03) and a trend toward lower mortality (29% vs 46%) compared to age- and cancer-matched controls, suggesting uveitis may serve as a favorable prognostic biomarker for ICI therapy.

In this systematic review and meta-analysis of anti-TNFα-refractory noninfectious uveitis, both intraclass and interclass biologic switching demonstrated meaningful response rates (77% vs. 89%, respectively), with interclass switching showing statistically superior outcomes in sensitivity analyses.

A centralized multidisciplinary retinoblastoma program at King Hussein Cancer Center achieved a 96% 5-year overall survival and 61% overall eye salvage rate across 1000 eyes from 601 patients over two decades, demonstrating that high-income country outcomes are attainable in resource-limited settings through structured care, capacity building, and telemedicine-supported international collaboration.

Metagenomic deep sequencing (MDS) of intraocular specimens from VRL patients identified gene mutations associated with chemotherapeutic resistance, including methotrexate resistance, with serial sampling in one patient revealing evolving resistance mutations likely reflecting clonal selection under treatment pressure.