RetinaDigest

In this prospective series of 72 eyes undergoing idiopathic ERM surgery, preoperative BCVA and photoreceptor-layer abnormalities (ellipsoid zone disruption and cotton ball sign) predicted worse postoperative BCVA, while preoperative metamorphopsia scores were the only predictors of postoperative metamorphopsia—no OCT structural parameter predicted metamorphopsia outcomes.

MacTel type 2-associated macular holes exhibit significantly reduced superficial vascular plexus vessel density compared to idiopathic macular holes, representing a distinct microvascular profile; however, MH etiology rather than microvascular parameters independently predicts short-term postoperative visual outcomes.

In this propensity score-matched analysis of 110 eyes undergoing primary PPV for giant retinal tear-related RRD, inferior GRTs were associated with a lower risk of single-surgery anatomical failure and better final visual acuity in macula-on eyes, with gas tamponade achieving comparable anatomical success but superior visual outcomes compared to silicone oil.

This dual-center retrospective series of 64 eyes challenges the traditional hamartomatous origin of CHRRPE, demonstrating that posterior hyaloid membrane traction is present in all cases and that surgical release leads to significant improvements in visual acuity, central subfield thickness, and pigmentary changes compared to observation.

This review establishes DRIL and DROL as critical OCT biomarkers of neuroretinal damage in diabetic retinal disease, demonstrating their superior prognostic value for visual outcomes and treatment response compared to traditional microvascular metrics.

Abstract not available — see full article for details.

Continuous pegcetacoplan treatment over 48 months reduced GA growth rate by up to 24% compared with projected sham, with early initiation preserving approximately three times more retinal tissue than delayed treatment in eyes with nonsubfoveal GA.

Abstract not available — see full article for details.

In a large real-world cohort of 1,929 treatment-naïve nAMD eyes, RPE tears occurred in 3.5% of cases following the aflibercept 2mg loading phase, with baseline PED height ≥244 µm identified as an optimal predictive threshold alongside several other clinical risk factors.

This study proposes a unified, disease-agnostic terminology—'sealed' and 'unsealed'—to classify RPE defects based on their anatomical relationship with the overlying photoreceptor layer and the presence or absence of subretinal fluid, consolidating previously disparate terms such as RPE aperture, SMARPE, and RPED devoid of RPE.

Polarimetric entropy (PE) maps derived from PS-OCT identified 97% of NIRAF-dark lesions in CSC with high spatial correspondence, and complex CSC demonstrated larger lesion areas and greater RPE PE loss compared to simple CSC, suggesting PE as a quantitative RPE-specific biomarker for disease severity classification.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In stage 2-3 type 3 macular neovascularization treated with aflibercept using a treat-and-extend regimen, BCVA at week 16 strongly predicted final visual outcomes, while younger age was associated with higher risk of lesion reactivation—though reactivation did not result in significant visual loss.

A retrospective Indian case-control study of 101 PCV patients and 101 controls found systemic hypertension to be a significant independent risk factor for PCV (adjusted OR 3.43), with the association particularly pronounced in patients over 70 years and in males.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Ultra-widefield OCT angiography (UWF-OCTA) identifies two distinct peripheral vascular phenotypes in retinitis pigmentosa (RP) and establishes the capillary non-perfusion zone (CNZ) area as a robust quantitative biomarker, enabling a validated 4-stage severity grading system with strong structure-function correlations.

Anemia of prematurity (AOP) is an independent risk factor for retinopathy of prematurity (ROP) across all gestational age and birth weight strata, with the strongest associations paradoxically observed in later preterm (32–36 weeks) and heavier (≥1500 g) neonates traditionally considered low risk.

Late recurrence of Coats' disease occurred in 10.3% of patients at a mean interval of 53 months after complete resolution, predominantly in eyes with milder initial disease, and was most commonly asymptomatic—underscoring the need for long-term surveillance even after apparent cure.

In a 10-year retrospective cohort of pediatric noninfectious posterior and panuveitis, ocular sequelae were nearly universal (98.1%), with glaucoma and vitreous opacities as the strongest drivers of visual decline, while methotrexate use was independently associated with visual preservation.

Abstract not available — see full article for details.

An international expert consensus taskforce established multimodal imaging guidelines for Behçet disease uveitis, identifying color fundus photography, fundus fluorescein angiography, and OCT as the primary modalities for diagnosis, disease monitoring, and complication detection.

Abstract not available — see full article for details.

A 10-year-old boy with severe atopic dermatitis developed relentless placoid chorioretinitis (RPC) temporally associated with dupilumab use, with disease improvement following drug discontinuation and immunosuppressive therapy including adalimumab.

In this multicenter retrospective cohort of 287 eyes with CSCR, immune-mediated disease status independently predicted poorer visual outcomes and higher recurrence rates (OR 2.64), with steroid-exposed immune-mediated cases demonstrating the most severe structural disease at baseline.

In choroidal melanoma patients requiring secondary therapy after initial plaque brachytherapy, GEP class and PRAME status remained concordant in 84% and 87% of cases, respectively, with NGS findings unchanged in all patients with paired results, supporting the reliability of repeat tumor biopsy biomarkers in this setting.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a single-center retrospective study with 10-year mean follow-up, combined PPV and Gore-Tex (PTFE) sutured scleral-fixated IOL implantation demonstrated durable visual improvement and a low rate of suture-related complications, with no cases of endophthalmitis or suture breakage.

Among four multimodal large language models evaluated for retinal fundus photograph diagnosis, ChatGPT-4o substantially outperformed Claude 3.5 Sonnet, Grok-2, and Gemini 1.5 (75% vs. 14–18% accuracy), though none are yet ready for unsupported clinical deployment.