RetinaDigest

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Transscleral fine-needle aspiration biopsy (FNAB) prior to irradiation for uveal melanoma is safe, with no significant increase in extraocular relapse, metastasis-free interval, or overall survival compared to matched non-biopsied controls over a 10-year period.

Using swept-source OCT, Spaide identifies two morphologically distinct forms of peripheral degenerative retinoschisis—columnar and bullous—suggesting that while vitreous traction may initiate schisis, progressive cavity enlargement in bullous retinoschisis likely involves loss of Müller cell structural support and impaired intraretinal fluid regulation rather than sustained mechanical traction alone.

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Higher Charlson Comorbidity Index (CCI) scores independently predict worse visual acuity outcomes at one year in patients with macular edema secondary to retinal vein occlusion, with each one-point CCI increase associated with 0.38 fewer ETDRS letters in the overall cohort and 0.72 fewer letters in the most comorbid patients.

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A national survey of U.S. retina specialists found that while over 90% actively manage inherited retinal disease (IRD) patients and order genetic testing, fewer than half feel confident interpreting results, revealing significant gaps in practice consistency and expertise.

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A systematic screen of 9,139 knockout mouse lines identified 18 candidate genes exhibiting concurrent retinal and inner ear abnormalities, representing potential novel causative genes for Usher syndrome warranting further human genetic investigation.

A systematic screen of 9,139 knockout mouse lines identified 18 candidate genes exhibiting concurrent retinal and inner ear abnormalities, representing potential novel causative genes for Usher syndrome warranting further human genetic investigation.

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In a retrospective case series of 12 patients with treatment-refractory non-infectious uveitis, off-label upadacitinib (JAK-1 inhibitor) achieved complete inflammation control in 41.7% of patients but failed entirely in 33.3%, representing the first documented report of treatment failure with this agent.

A digital mindfulness app (Calm Health) used for ≥10 minutes daily over 8 weeks significantly reduced anxiety, depression, and perceived stress in adults with non-infectious uveitis compared to waitlist controls, though vision-related quality of life scores did not differ significantly between groups.

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This case report describes the first documented intraocular infection caused by Shinella species, a soil-and-water-dwelling Gram-negative bacillus, successfully diagnosed via metagenomic next-generation sequencing (mNGS) and treated with pars plana vitrectomy combined with targeted antibiotics.