RetinaDigest

Prophylactic laser treatment of lattice degeneration in fellow eyes of patients with retinal breaks in the first eye did not significantly reduce the risk of new retinal breaks or rhegmatogenous retinal detachment (RRD) over a mean follow-up of 5 years.

In this retrospective series of 15 eyes with morning glory syndrome-associated retinal detachment (MGS-RD), the final anatomical success rate was only 46.7%, with advanced PVR (grade C), younger age (≤3 years), and closed-funnel configuration strongly predicting surgical failure.

Patients with a fellow-eye history of retinal detachment face a significantly higher short-term risk of retinal detachment following laser retinopexy for retinal tears, despite no corresponding increase in repeat laser treatment rates.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a large retrospective cohort of over 127,000 patients with type 2 diabetes, worsening anemia severity was associated with a stepwise increase in 1-year risk of diabetic macular edema (up to HR 2.32 for severe anemia), and iron supplementation in anemic patients was associated with a modest but significant reduction in DME risk.

Abstract not available — see full article for details.

In youth aged 9–21 years with type 1 diabetes, OCT-detected neuroretinal thinning (GCL+IPL and outer retinal layers) was significantly associated with higher HbA1c, occurring even in the absence of clinically apparent diabetic retinal disease.

In a prospective series of 172 diabetic patients presenting to an academic retina clinic, only 8.1% had normal blood pressure, with 52.9% meeting criteria for stage 2 hypertension and 10.5% in hypertensive crisis—highlighting the high prevalence of uncontrolled hypertension even among patients already engaged in medical care.

In proliferative diabetic retinopathy, eyes with severe retinal non-perfusion paradoxically exhibit fewer visible lesions on ultra-wide field fundus photography, underscoring the risk of underestimating ischemic severity based on color fundus imaging alone.

Among DME patients lost to follow-up for ≥6 months who returned with stabilized vision, anti-VEGF retreatment yielded significantly lower visual and anatomical gains compared to those who returned with vision decline, with patients maintaining 20/50 or better acuity failing to achieve meaningful visual improvement despite anatomical response.

In a large target trial emulation using real-world EHR data, levodopa ± carbidopa use was associated with a ~30% reduction in 3-year conversion risk from non-neovascular to neovascular AMD, while DRD2 agonists showed no significant protective effect.

Mid-phase hyperfluorescent plaques (MPHP) on ICG-A are dynamic biomarkers of disease activity in CSCR, with PDT demonstrating the greatest reduction in both MPHP area and subretinal fluid compared to laser, eplerenone, or observation.

In this large IRIS Registry study of over 80,000 eyes, cataract surgery was associated with a modestly increased risk of conversion from dry to neovascular AMD (HR 1.22), but the effect was strongest in year 1 and dissipated by year 4, suggesting surveillance bias or undetected pre-existing neovascular disease rather than a true biological causation.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

In a propensity-score matched cohort study of over 25,000 hyperlipidemic patients, PCSK9 inhibitor use was associated with significantly lower risk of retinal vascular occlusions—both arterial and venous—compared to other lipid-lowering therapies, with risk reductions of up to 54% over seven years.

Abstract not available — see full article for details.

In a single-center series of nine Arabian Gulf patients undergoing bilateral subretinal voretigene neparvovec-rzyl for RPE65-related retinal dystrophy, scotopic vision improved in all patients treated before age 40, though universal postoperative chorioretinal atrophy (CRA) was observed and was associated with BCVA loss in two patients with progressive central CRA.

A national survey of U.S. retina specialists revealed that while over 90% actively manage inherited retinal disease (IRD) patients and order genetic testing, fewer than half feel confident interpreting results, underscoring significant gaps in genetic literacy and counseling resources.

Abstract not available — see full article for details.

In this retrospective study of 181 eyes treated for ROP, intravitreal bevacizumab was associated with significantly lower rates of early retreatment (1.7%) compared to laser photocoagulation (21.5%), and delayed the need for additional intervention when retreatment was required.

In a retrospective cohort of 144 patients with ocular toxoplasmosis, Latin American origin was independently associated with atypical disease presentation, higher recurrence rates, and worse visual acuity outcomes compared with European patients, supporting a more aggressive disease phenotype in this population.

Persistent placoid maculopathy (PPM) carries a poor visual prognosis, with severe visual loss in one-third of eyes and choroidal neovascularization in 65% of eyes at long-term follow-up; systemic treatment was significantly associated with better final visual acuity.

This retrospective case series from Moorfields Eye Hospital describes three immunosuppressed patients who developed delayed-onset CMV retinitis (8–14+ months post-implantation) following intravitreal 0.2 µg/day fluocinolone acetonide (FAc) implantation, highlighting a rare but vision-threatening complication requiring prompt recognition and antiviral intervention.

In non-HIV patients with intraocular CMV infection, ultrawide-field fluorescein angiography (UWFFA) reveals extensive pan-retinal capillary non-perfusion reflecting an occlusive vasculopathy, which may present with or without classic necrotizing retinitis and carries a guarded prognosis despite antiviral therapy.

A 59-year-old woman with bilateral optic disc edema and CSF anti-GFAP positivity was initially misdiagnosed with autoimmune GFAP astrocytopathy, but longitudinal multimodal imaging ultimately revealed late-onset Vogt-Koyanagi-Harada disease with characteristic choroidal inflammation, guiding appropriate immunosuppressive therapy.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

A case of Nocardia brasiliensis endophthalmitis in a 67-year-old diabetic man highlights the risk of diagnostic delay when the condition mimics uveitis, with fulminant progression to light perception vision despite aggressive antimicrobial and surgical treatment.