RetinaDigest

A ring indenter scleral self-indentation technique demonstrated equivalent safety and efficacy to conventional assistant-assisted indentation for basal vitrectomy in primary rhegmatogenous retinal detachment repair, with comparable reattachment rates and visual outcomes.

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Among diabetic macular edema patients who returned after being lost to follow-up for >6 months, approximately 27% had persistent vision loss ≥10 letters at 12 months despite resuming anti-VEGF treatment.

Treatment-naïve diabetic macular edema (DME) showed distinct inflammatory profiles compared to Irvine-Gass syndrome, with lower aqueous cytokine levels and higher frequency of hyperreflective foci on OCT, suggesting early-stage disease characteristics.

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Switching plateau-phase neovascular AMD eyes to aflibercept 8 mg improved anatomical outcomes with 69% achieving dry maculae at 12 months and enabled treatment interval extension from 6.0 to 7.8 weeks, though with a slight decline in visual acuity.

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Abstract not available — see full article for details.

This 15-year prospective cohort study of 152 highly myopic eyes found that 3D eye shape, particularly nasally distorted and conical phenotypes, significantly predicts structural and functional deterioration including faster axial elongation, choroidal thinning, and myopic macular degeneration progression.

Identical twins with COQ2-related retinopathy presented with an atypical phenotype mimicking intermediate uveitis with cystoid macular edema, rather than the typical retinitis pigmentosa-like presentation, expanding the recognized spectrum of this genetic condition.

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Noncontact handheld OCT caused significantly less stress in preterm infants during ROP examinations compared to contact fundus photography, with lower pain scores, reduced changes in vital signs, and fewer adverse events.

Hydroxychloroquine demonstrated efficacy as a steroid-sparing agent in sarcoidosis-associated and idiopathic uveitis, with 55% of SAU and 40% of IdU patients achieving successful treatment at last visit while significantly reducing prednisone requirements.

Adalimumab effectively controlled non-infectious uveitis in Japanese patients, achieving inactive disease in 61.5% at 12 months with significant steroid-sparing benefits, though etiology-dependent differences in methotrexate requirements and dose spacing outcomes were observed.

This retrospective case series of 9 patients demonstrates that HLA-B27-associated uveitis can present with severe vitritis and posterior segment involvement, challenging traditional diagnostic expectations and leading to potential misdiagnosis including endogenous endophthalmitis.

Ocular inflammation significantly increases the risk of developing anti-adalimumab antibodies (AAA) in patients with autoimmune diseases, with over 21% of adalimumab-treated patients developing these antibodies.

In this real-world study of 117 eyes with non-infectious posterior uveitis, fluocinolone acetonide implants provided more sustained anatomical control with fewer injections compared to dexamethasone implants, but required greater IOP management.

This study identified Bruch's membrane disruption (94.7% vs 6.1% in controls) and inner retinal layer herniation (57.9% vs 4.3%) as highly characteristic OCT features that can help diagnose inactive MFCPU/PIC lesions when active inflammation is absent.

This case report documents the first cytological evidence of CD163+ foamy histiocytes in vitreous humor of a patient with West Nile Virus-associated chorioretinitis, identified through diagnostic vitrectomy.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

This case report documents the first reported instance of postoperative endophthalmitis progressing to panophthalmitis in a silicone oil-filled eye following pars plana vitrectomy, highlighting the rarity and poor outcomes of this complication.

This retrospective study of 46 eyes found no significant differences in visual outcomes between MRSA and MSSA endophthalmitis, though exogenous cases had higher rates of enucleation/evisceration compared to endogenous cases.

This retrospective study of 50 eyes with culture-proven endogenous endophthalmitis found that 46% were fungal in origin, 61% lacked systemic symptoms at presentation, and visual outcomes remained poor despite treatment with 52% achieving ≥20/400 vision.