RetinaDigest

Weekly curated literature from top retina and ophthalmology journals

12 articles
5 categories
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AMD & Macular Degeneration3 articles

Neovascular AMD, geographic atrophy, submacular hemorrhage

Re: Shaheen et al: Efficacy and Safety of Anti-VEGF Injections and Surgery for Age-Related Macular Degeneration-Related Submacular Hemorrhage: A Systematic Review and Meta-analysis (Ophthalmol Retina. 2025;9:4-12).

Pierre-Henry & Creuzot-Garcher
Ophthalmol RetinaMay 15, 2026

Abstract not available — see full article for details.

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Time-in-Range and Time-in-Maintenance: Longitudinal Biomarkers in Home Vision Monitoring of Macular Disease - A Retrospective Cohort Study.

Dieu, Panjwani … Kozak
RetinaMay 15, 2026

This retrospective study introduces Time-in-Range (TIR) and Time-in-Maintenance (TIM) as novel longitudinal biomarkers derived from smartphone-based home vision monitoring in macular disease patients. TIR-hyperacuity correlated with better visual and anatomical outcomes, while TIM-hyperacuity was associated with increased injection frequency.

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Improving Efficiency in Geographic Atrophy Clinical Trials Using Run-In Phases or Single-Arm Designs.

Hou, von der Emde … Keenan
JAMA OphthalmolMay 14, 2026

Incorporating run-in phases into randomized controlled trials or using single-arm designs can significantly reduce sample size requirements for geographic atrophy clinical trials by leveraging the inherent stability of GA enlargement rates over time.

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Vascular Occlusions1 article

CRVO, BRVO, retinal ischemia, macular edema from RVO

Arteriovenous Malformation: Ultra-Widefield Fundus Imaging and En Face OCT.

Feo, Afzali & Sarraf
Ophthalmol RetinaMay 11, 2026

Abstract not available — see full article for details.

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Posterior Uveitis5 articles

Posterior uveitis, panuveitis, chorioretinitis, CMV retinitis, ocular inflammation

Concurrent cytomegalovirus iridocyclitis and vitreoretinal lymphoma in the same eye during long-term infliximab therapy: a case report.

Goto, Kunimatsu-Sanuki … Hori
J Ophthalmic Inflamm InfectMay 14, 2026

This case report describes the rare concurrent development of CMV iridocyclitis and vitreoretinal lymphoma in the same eye of a patient on long-term infliximab therapy, highlighting the diagnostic challenges and risks associated with prolonged immunosuppression.

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PERIVASCULAR MULTIFOCAL CHOROIDITIS WITH PANUVEITIS: Clinical and Multimodal Imaging Features.

Feo, Quarta … Tsui
RetinaMay 13, 2026

This study describes a distinct perivascular phenotype of multifocal choroiditis with panuveitis (PV-MFCPU) characterized by reproducible perivascular distribution of lesions along retinal vessels, with good visual outcomes and potential for choroidal neovascularization development.

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Evidence and Consensus Based Imaging Guidelines in Cytomegalovirus retinitis. Multimodal imaging in Uveitis (MUV) Taskforce Report 15.

Leal, Agarwal …
Ophthalmol RetinaMay 11, 2026

International expert consensus establishes evidence-based multimodal imaging guidelines for cytomegalovirus retinitis (CMVR), confirming color fundus photography as the primary imaging modality with OCT and fundus autofluorescence serving important complementary roles.

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Multifocal Fungal Retinitis Caused by Lasiodiplodia theobromae.

Sunny, Balakrishnan & Rathinam
Ophthalmol RetinaMay 10, 2026

Abstract not available — see full article for details.

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Six-Year Migratory Course of Acute Zonal Occult Outer Retinopathy with Partial Ellipsoid Zone Recovery.

Zhan, Huang & Zhao
Ophthalmol RetinaMay 10, 2026

Abstract not available — see full article for details.

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Ocular Oncology1 article

Uveal melanoma, retinoblastoma, choroidal tumors, ocular metastases

One-Year Tumor Volume Regression Predicts Survival After I-125 Plaque Brachytherapy for Posterior Uveal Melanoma.

Dave, Taylor Gonzalez … Wilson
Am J OphthalmolMay 12, 2026

One-year tumor volume regression following I-125 plaque brachytherapy for uveal melanoma predicts overall survival, with intermediate regression (33.3-75%) conferring the greatest survival benefit compared to delayed or accelerated regression patterns.

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Complications & Safety2 articles

Endophthalmitis, surgical complications, drug safety, adverse events

Characterization of Pentosan Polysulfate Sodium Maculopathy With Fluorescence Lifetime Imaging.

Nagel, Dysli … Borooah
RetinaMay 15, 2026

Fluorescence lifetime imaging ophthalmoscopy (FLIO) demonstrates significantly prolonged fluorescence lifetimes in pentosan polysulfate sodium (PPS) maculopathy patients compared to controls, with lifetime values correlating with disease severity.

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Comparing Refractive Outcomes of Secondary Lens Surgery between Ophthalmology Subspecialties in Patients with Good Final Vision.

Sharma, Israilevich … Starr
RetinaMay 13, 2026

This retrospective study of 278 eyes found that vitreoretinal and anterior segment surgeons achieved equivalent refractive outcomes after secondary intraocular lens surgery in patients with good final vision (20/50 or better).

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