RetinaDigest

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Macular OCTA-derived geometric perfusion deficits in the deep capillary plexus (GPDd) are a robust biomarker for retinal nonperfusion across all retinal regions in diabetic eyes, while foveal avascular zone (FAZ) enlargement indicates only posterior ischemia.

In DME, fluocinolone acetonide (FAc) as baseline therapy achieved similar visual and anatomical outcomes to aflibercept but required significantly fewer total injections over 18 months, despite a higher incidence of cataracts and increased intraocular pressure.

Combining intravitreal dexamethasone implant with navigated subthreshold micropulse yellow laser significantly improved visual acuity and reduced central subfield thickness, while extending the retreatment-free interval for diabetic macular edema patients over 12 months compared to dexamethasone monotherapy.

Centenarian patients with neovascular AMD can maintain vision with long-term anti-VEGF therapy, underscoring the need for tailored management strategies.

Despite anti-VEGF transforming nAMD therapy, visual acuity gains have plateaued; future progress should prioritize meaningful visual function improvements over solely achieving a dry retina or extending dosing intervals.

Hyperreflective foci contiguous with the RPE (rpeHRF) are associated with worsening visual function across the spectrum of aging, early, and intermediate AMD, with their burden increasing alongside disease severity.

Retinal abnormalities, particularly pigmentary changes and RPE/ellipsoid zone disruption, are the most common ophthalmic manifestations of Danon disease and can prompt earlier diagnosis of this life-threatening systemic disorder.

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This multigenerational case series highlights familial granulomatous uveitis suggestive of Blau syndrome in India, emphasizing the importance of early diagnosis and immunomodulatory therapy to prevent irreversible visual morbidity, particularly in the absence of genetic testing.

In pediatric presumed trematode-induced granulomatous intermediate uveitis (PTIGIU), lower presenting visual acuity and higher vitreous inflammation predict medical treatment failure and better response to early surgical intervention.

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Nearly half of phakic patients (46%) undergoing pars plana vitrectomy required cataract surgery within 2 years, with older age, baseline cataract, and vitrectomy for retinal detachment, macular hole, or epiretinal membrane significantly increasing this risk.

Among patients receiving intravitreal anti-VEGF therapy who experience stroke or myocardial infarction (MI), continuing injections peri-event was not associated with increased mortality or major functional morbidity and may even be associated with improved short-term outcomes.

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Post-injection endophthalmitis after a first anti-VEGF injection is rare (0.059%), typically presenting within 3-8 days, with prior intravitreal corticosteroid use and residence in U.S. territories identified as risk factors.