RetinaDigest

In high myopic macular holes, inverted ILM flap technique achieved superior closure rates compared to ILM peeling across different posterior staphyloma types and grades. Staphyloma morphology significantly influences surgical outcomes and vascular recovery patterns.

Abstract not available — see full article for details.

This retrospective study of 310 eyes found that phacoemulsification does not significantly increase the likelihood or speed of vitreomacular traction (VMT) release, with intrinsic patient factors being more predictive of outcomes.

In CSC patients awaiting PDT, prolonged subretinal fluid duration causes progressive outer nuclear layer thinning but does not significantly impact 12-month visual outcomes or treatment success.

Abstract not available — see full article for details.

Abstract not available — see full article for details.

Primary scleral buckle repair for rhegmatogenous retinal detachment in young adults achieves 80.3% single-surgery success at 12 months with favorable long-term visual outcomes, though 26.9% require fellow-eye intervention during follow-up.

The Vitreous Floater Functional Questionnaire (VFFQ-23) significantly outperformed the NEI VFQ-25 in predicting surgical decision-making and measuring post-operative improvement in patients with vision-degrading myodesopsia from vitreous floaters.

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Widefield SS-OCTA-derived metrics of retinal neovascularization burden, particularly elevated RNV lesions separated from the internal limiting membrane, predict vision-threatening complications in high-risk proliferative diabetic retinopathy with high accuracy.

Anti-VEGF treatment response for diabetic macular edema significantly decreases with patient age, with older patients showing less visual acuity improvement and higher rates of weak treatment response over 2 years.

OCT utilization increased significantly from 2013-2021 while fluorescein angiography declined, correlating with increased anti-VEGF injections and decreased panretinal photocoagulation usage in retinal disease management.

This retrospective study identified five distinct outer retinal layer deterioration patterns in diabetic serous macular detachment, with WEDGE pattern showing the best visual prognosis and DIFFUSE pattern having the poorest outcomes.

This study found that specific OCTA biomarkers, including neovascularization vessel density and deep capillary plexus changes, are associated with increased risk of cardiovascular events and mortality in diabetic retinopathy patients.

In 74 eyes with diabetic macular edema, baseline HbA1c levels showed weak correlation with visual acuity improvement but did not predict faricimab treatment response. Faricimab loading phase demonstrated significant anatomical and functional improvements regardless of glycemic control status.

Abstract not available — see full article for details.

This pilot study describes choroidal synphlebia, a newly recognized choroidal venous phenotype characterized by confluent venous structures ≥750 µm, predominantly associated with central serous chorioretinopathy and potentially explaining treatment-resistant cases.

This randomized controlled trial demonstrated that intravitreal brolucizumab effectively resolves persistent subretinal fluid in chronic central serous chorioretinopathy without choroidal neovascularization, with 77% of treated eyes achieving >20% reduction in central macular thickness at 1 month.

Kerwin et al. developed Atrophy Advisor, a clinical decision tool that combines geographic atrophy progression rates and personalized lifespan estimates to guide complement factor inhibitor treatment decisions in dry AMD patients.

Basal laminar deposits (BLamD) are consistently present in eyes with pseudodrusen and may serve as indicators of AMD severity, potentially contributing to rapidly progressive atrophy when associated with subretinal drusenoid deposits.

Retinal fingerprint pattern (RFP) was identified in 18.3% of central serous chorioretinopathy (CSCR) eyes and was associated with greater subretinal fluid height and significantly better anatomical outcomes including higher rates of complete fluid resolution.

Machine learning analysis of OCT images achieved 87.10% accuracy in differentiating central serous chorioretinopathy, polypoidal choroidal vasculopathy, and Vogt-Koyanagi-Harada disease, with best performance using single foveal OCT scans combined with infrared photography.

A novel surgical technique demonstrates that subretinal hematomas can be directed away from the fovea by creating an artificial retinal detachment with subretinal tPA injection at a strategic location temporal to the macula.

Loop-shaped neovascular morphology on baseline OCTA independently predicted poor anatomical response to anti-VEGF therapy in treatment-naïve neovascular AMD patients. This biomarker may enable early risk stratification and guide personalized treatment approaches.

Among high genetic risk patients with early/intermediate AMD, adopting healthy lifestyle behaviors could prevent 56-60% of progression to advanced AMD, with unhealthy behaviors increasing progression risk 3-5 fold.

Chronic CSCR patients with subretinal hyperreflective material (SHRM) present with worse baseline vision and have higher rates of persistent subretinal fluid and ellipsoid zone loss despite visual improvement after treatment.

A deep learning model trained exclusively on Spectralis OCT scans demonstrated robust performance for multiple macular disease detection across different OCT vendors (Heidelberg and Zeiss) with AUROC values ranging from 0.754-0.999, achieving high negative predictive values (>97.5%) and manageable miss rates for urgent cases (6-7%).

This retrospective study of 100 treatment-naïve neovascular AMD patients found that aflibercept 8 mg and faricimab achieved statistically equivalent visual and anatomical outcomes after three monthly loading injections.

OCTA showed poor diagnostic performance compared to SD-OCT for detecting neovascular AMD recurrence, with sensitivity of 72% but specificity of only 27%, and did not reduce unnecessary injections or change treatment decisions.

Hyperreflective foci (HRF) and subretinal drusenoid deposits (SDD) show distinct progression patterns in AMD, with HRF increasing risk for both geographic atrophy and neovascular AMD, while SDD increases risk only for geographic atrophy.

Pediatric sickle cell disease patients showed significantly reduced choroidal vascularity index (54% vs 69% in controls) that correlated with decreased retinal vessel density and lower hemoglobin levels, suggesting choroidal ischemia contributes to sickle cell maculopathy pathogenesis.

Epiretinal membrane (ERM) formation peaks within 3 months after retinal vein occlusion (RVO), with highest surgical intervention rates occurring at 1 year for BRVO and 3 years for CRVO in untreated eyes.

In pathologic myopia, prior retinal inflammation consistent with punctate inner choroidopathy significantly accelerates atrophic progression, doubling the annual atrophy expansion rate compared to non-inflamed controls.

This large Chinese cohort study of 58 CNGA1-associated retinitis pigmentosa patients identified a distinct natural history pattern with visual acuity remaining stable until age 30.7 years before declining, while visual field loss occurs earlier, suggesting an optimal intervention window between the 3rd and 4th decades of life.

Autosomal recessive bestrophinopathy shows wide phenotypic variability from mild macular involvement to severe panretinal degeneration, but visual impairment risk is primarily driven by primary angle closure rather than fundus lesion severity.

This prospective study of 7 patients with the pathogenic p.Gly208Asp PRPH2 variant demonstrates significant retinal thinning and expansion of atrophic areas over 1 year, establishing multimodal imaging markers for monitoring central areolar chorioretinal dystrophy progression.

MERTK-related retinopathy presents as juvenile rod-cone dystrophy with early macular involvement, typically causing significant visual loss by teenage years with characteristic asymmetric central macular atrophy.

Abstract not available — see full article for details.

This longitudinal study of 107 XLRS patients demonstrates a triphasic pattern of visual decline with optimal therapeutic window in early adulthood, and validates automated cyst-cavity volume as a quantitative biomarker for monitoring disease progression.

Anti-VEGF therapy effectively treated 79% of stage 2 FEVR cases diagnosed under 3 months of age and promoted continued peripheral vascular growth, with most eyes showing regression of vascular activity.

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This review examines the emerging applications of artificial intelligence in uveitis diagnosis and monitoring, highlighting AI's potential to automate multimodal imaging interpretation and improve clinical efficiency in ocular inflammatory disease management.

In this multicenter study of 336 sarcoid uveitis patients, ocular relapses occurred in two-thirds of patients with macular edema and persistent inflammation at baseline predicting shorter relapse-free survival, while visual impairment remained low at 6.5% after median 7.8-year follow-up.

The ADVISE trial demonstrated that adalimumab was superior to conventional immunosuppression for achieving corticosteroid sparing at 6 months and corticosteroid discontinuation at 12 months in patients with noninfectious intermediate, posterior, or panuveitis.

This retrospective study of 41 patients with CMV retinitis found that pediatric patients demonstrate more severe disease with higher rates of bilateral involvement, extensive retinal damage, and retinal detachment compared to HIV-positive and HIV-negative adults.

This retrospective study of 1,081 uveitis patients found that 36.4% had at least one no-show appointment, with younger age, Black race, Medicaid insurance, and blindness being significant risk factors for missed appointments.

This Indonesian cohort study of 47 ocular syphilis patients found a 9:1 male predominance with 78.7% HIV co-infection, particularly among men who have sex with men, and demonstrated more severe ocular inflammation in HIV-positive patients.

RPE disruption lesions on OCT are frequently occurring yet underrecognized findings in vitreoretinal lymphoma, present in 78% of affected eyes and potentially serving as diagnostic clues for VRL identification.

Aqueous humor liquid biopsy via anterior chamber paracentesis demonstrated exceptional safety in retinoblastoma patients, with only 1 mild complication among 1,203 procedures (0.08% complication rate) and no severe adverse outcomes.

FAERS database analysis revealed increased reporting of various eye disorders, including retinopathy, cataracts, and optic ischemic neuropathy, associated with GLP-1 receptor agonists compared to metformin in both diabetic and non-diabetic patients.

In postprocedural acute endophthalmitis, infections with virulent nonsurface commensal organisms (Streptococcus, Enterococcus) result in significantly worse visual outcomes and higher complication rates compared to coagulase-negative Staphylococcus infections.

Multidrug-resistant bacterial endophthalmitis after cataract surgery occurs in 7.8% of cases, predominantly caused by gram-negative bacilli, with colistin showing superior efficacy compared to other antibiotics for treatment.

This meta-analysis of 54,006 patients found that pars plana vitrectomy increases the risk of ocular hypertension (5.6%) and glaucoma (3.9%), with pseudophakic eyes having substantially higher odds of developing these complications compared to phakic eyes.

Abstract not available — see full article for details.