RetinaDigest

This meta-analysis of 20 studies (1,841 eyes) found that preoperative OCT biomarkers, particularly intact photoreceptor ellipsoid zone and external limiting membrane, significantly predict better visual outcomes after macula-off rhegmatogenous retinal detachment surgery. However, findings should be interpreted cautiously due to low-quality evidence and high study heterogeneity.

International expert consensus from three major ophthalmology organizations established 49 standardized recommendations for intraocular foreign body (IOFB) management using a modified Delphi method. The guidelines provide systematic approaches to diagnosis, characterization, management, and outcomes assessment for IOFB cases.

Pars plana vitrectomy with suprachoroidal viscopexy (VIT-SCVEXY) demonstrated comparable reattachment rates and visual outcomes to traditional vitrectomy with scleral buckle for rhegmatogenous retinal detachment repair, with a 91.6% success rate at final follow-up.

Tractional lamellar macular holes can be managed conservatively, as patients maintained stable visual acuity over a mean 3.7-year follow-up despite anatomical progression of the hole diameter.

Swept source OCT reveals that optic disc pit maculopathy involves a complex spectrum of deep optic nerve abnormalities including lamina cribrosa defects, intraneural cavitations, and multiple pathways for fluid entry into the retina.

In this retrospective series of 157 eyes with Boston Type 1 keratoprosthesis, 17.2% developed retinal detachment within 8 years, with aniridia being a significant risk factor (OR: 2.79).

A novel non-inverted ILM free flap technique combined with SPOT (sub-PFCL injection of OVD) achieved 100% anatomical closure in 8 persistent unclosed macular holes within one month, with visual acuity improvement in all cases.

In pediatric rhegmatogenous retinal detachment, older age and female gender were associated with more favorable presentation characteristics, while insurance status significantly influenced follow-up compliance but socioeconomic factors did not impact surgical outcomes.

Epiretinal membrane develops in 13.4% of eyes following scleral buckling for rhegmatogenous retinal detachment, with most cases managed conservatively and showing visual improvement over time.

This multimodal imaging study identifies angular sign of Henle fiber layer hyperreflectivity as a distinctive acute OCT finding in contusion maculopathy that correlates with photoreceptor disruption and variable visual outcomes.

This retrospective study of 794 patients found that pneumatic retinopexy and greater detachment extent significantly increase recurrence risk, while older age and male sex predict fellow eye involvement in rhegmatogenous retinal detachment.

In patients with Marfan syndrome, 33.1% developed rhegmatogenous retinal detachment over long-term follow-up, with successful reattachment achieved in 69.2% after primary repair and higher rates after secondary procedures.

PVR grade C significantly increases both the incidence and height of outer retinal folds (ORFs) one month after pars plana vitrectomy for rhegmatogenous retinal detachment, suggesting ORFs may serve as markers of retinal remodeling severity.

This systematic review and meta-analysis of 17 studies (162,695 examinations) found EyeArt AI system achieved 95% sensitivity and 81% specificity for detecting referable diabetic retinopathy from fundus photographs, supporting its use for autonomous screening in primary care settings.

In type 2 diabetic patients without retinopathy, ganglion cell-inner plexiform layer thickness decreased 5-fold faster than controls over 2 years, while capillary vessel density remained unchanged, suggesting neurodegeneration precedes microvascular changes.

Swept-source OCTA identified three key biomarkers associated with tractional retinal detachment development in PDR: large retinal nonperfusion areas, extensive neovascularization (>4 disc diameters), and tabletop neovascularization with anterior displacement.

Adaptive optics scanning laser ophthalmoscopy detected progressive photoreceptor loss and arteriolar wall thickening in diabetes patients, with changes correlating with diabetic retinopathy severity at the cellular level.

A systematic review and meta-analysis of 53 studies found no significant difference in diabetic retinopathy prevalence between American Indian/Alaska Native (21%) and non-Indigenous American (20%) patients with diabetes.

This systematic review and meta-analysis of 27 studies identified five OCT biomarkers consistently associated with worse visual acuity outcomes in diabetic macular edema patients at 6, 12, and 24 months after treatment initiation.

In this large cohort study of 608 PDR vitrectomy cases, preoperative anti-VEGF reduced postoperative vitreous hemorrhage but not traction retinal detachment risk, with optimal timing being 4-7 days before surgery.

An international expert panel established consensus guidelines defining pachydrusen as distinct drusen subtypes ≥125 μm with irregular, multilobulated morphology and sharp borders, associated with increased choroidal thickness and ethnicity-related prevalence variations.

Real-world use of intravitreal pegcetacoplan in 154 eyes with geographic atrophy demonstrated a 37% reduction in GA growth rate compared to pre-treatment rates, with similar efficacy for both foveal and nonfoveal lesions.

Lower socioeconomic status was associated with worse visual outcomes in wet AMD patients, with income level affecting both baseline and final visual acuity as well as choice of anti-VEGF agent.

Anti-VEGF therapy for neovascular AMD causes extensive choroidal thinning across a wide retinal area, with greater thinning associated with better fluid resolution in pachychoroid neovasculopathy patients.

Aflibercept 8 mg demonstrated non-inferiority to aflibercept 2 mg in treatment-naive nAMD patients through 96 weeks, allowing extended dosing intervals of 12-24 weeks while maintaining similar visual and anatomic outcomes with comparable safety.

This study describes age-related retinal pigment epithelium disease (ARPED), a newly characterized retinal condition affecting older patients that shows primary RPE involvement without typical AMD features like drusen or pachychoroid characteristics.

Faricimab induces significant morphometric changes in macular neovascularization networks, with greater effects in treatment-naive eyes compared to switched eyes, primarily occurring during the loading phase.

This large retrospective cohort study found that adults with atopic dermatitis have a significantly increased risk of developing age-related macular degeneration, with hazard ratios of 1.97 in the US cohort and 1.25 in the Taiwan cohort.

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This nationwide cohort study of 39,540 patients found that retinal vascular occlusion is associated with a 57% increased risk of Alzheimer's disease and 76% increased risk of vascular dementia.

This large-scale retrospective cohort study found that exogenous testosterone use significantly increases the risk of central serous chorioretinopathy by over 8-fold (adjusted OR: 8.05).

AI algorithms showed promise for detecting sickle cell maculopathy in pediatric patients using OCT imaging, with random forest achieving 96% accuracy in identifying retinal thinning.

This longitudinal study of 57 RAO eyes identified baseline macular ischemic area and foveal avascular zone (FAZ) area as independent predictors of final visual acuity, with potential for microvascular reperfusion in eyes with limited initial involvement.

In RVO patients without macular edema at presentation, PAMM (particularly globular subtype) serves as a protective factor, with 42% developing macular edema within one year despite this initial resistance.

Anti-VEGF therapy for stages 3 and 4 proliferative sickle cell retinopathy achieved disease control in 93% of eyes within one month, with visual improvement particularly notable in stage 4 cases and minimal need for vitrectomy.

Voretigene neparvovec gene therapy in 14 pediatric patients with RPE65-associated retinopathy demonstrated visual improvements measurable by pattern VEPs, though visual acuity improvements were modest when excluding off-chart conversions.

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Female carriers of RPGR ORF15 variants causing X-linked cone dystrophy exhibit a distinct phenotype with mild cone dysfunction, macular changes limited to the posterior pole, and preserved peripheral retina, differing from carriers of rod-cone dystrophy variants.

Insufficient information provided - only title and authors are available for this case report on the co-occurrence of retinitis pigmentosa and Von Hippel-Lindau disease.

A smartphone-driven AR headset significantly improved mobility performance and visual field function in retinitis pigmentosa patients, with 88% able to complete mobility testing at 1 lux compared to 0% without the device.

Researchers developed and validated a commercially available 2-color dark-adapted perimetry protocol using the Octopus 900 Pro that can differentiate rod and cone function in retinitis pigmentosa patients, demonstrating superior sensitivity to early rod function loss compared to standard perimetry.

This case series of 5 patients with ROSAH syndrome identifies distinct ocular manifestations including persistent optic disc edema and progressive retinal degeneration resembling retinitis pigmentosa, with a novel ALPK1 mutation (T237A) causing a milder phenotype with isolated ocular symptoms.

A novel noninvasive imaging technique using ultra-widefield scanning laser ophthalmoscopy with monochromatic wavelengths can detect ocular amyloidosis deposits with high specificity (100%) by identifying characteristic patterns on red and green filtered images.

A deep learning AI tool accurately quantified intraretinal fluid in retinitis pigmentosa-associated macular edema, demonstrating that oral acetazolamide significantly reduces fluid volume and improves visual acuity over time, while topical carbonic anhydrase inhibitors show no significant benefit.

This case report describes a novel presentation of circinate midperipheral vitelliform dystrophy with macular sparing in the father of a patient with Best disease, suggesting potential genetic heterogeneity in vitelliform dystrophies.

A Taiwanese expert panel developed evidence-based consensus recommendations for ROP management, endorsing both anti-VEGF therapy and laser photocoagulation as acceptable first-line treatments for type 1 ROP with individualized treatment selection.

This retrospective study of 92 eyes with FEVR found that most patients (62%) required no treatment, but advanced stages (≥4) were significantly associated with poor visual outcomes despite surgical intervention.

FEVR patients without foveal hypoplasia demonstrate irregular foveal avascular zone morphology and abnormal cone photoreceptor distribution, with lower foveal but higher parafoveal cone densities compared to healthy controls.

This retrospective cohort study of 6,952 children found no association between COVID-19 infection and retinal hemorrhage across multiple time intervals. All children with both positive COVID-19 tests and retinal hemorrhages had alternative explanatory causes.

This case report describes a rare occurrence of a giant macular hole developing in an eye with regressed retinopathy of prematurity, highlighting an unusual late complication in ROP patients.

Risk-stratified ROP screening using TWO-ROP and FIRST-ROP algorithms can significantly reduce neonatal healthcare costs in the United States while maintaining safety by decreasing the number of required inpatient examinations.

A case report describes APMPPE presenting with unilateral bacillary layer detachment (BALAD), emphasizing the importance of multimodal imaging for differential diagnosis of choroiditis and non-invasive monitoring of treatment response.

Insufficient information provided - only title and authors were given without abstract content to summarize the clinical findings regarding HELLP syndrome-associated chorioretinopathy with uveal effusion.

A French study of 72 patients with ocular syphilis found that diagnostic delays >4 weeks occurred only in patients who first consulted private practice ophthalmologists, and longer delays were associated with poorer visual outcomes.

AI-driven OCT analysis identified larger baseline lesion volume and longer disease duration as key predictors of secondary CNV development in patients with punctate inner choroidopathy and multifocal choroiditis.

This systematic review and meta-analysis of 34 studies involving over 10 million subjects demonstrates that psoriasis patients have significantly increased risk for multiple ocular comorbidities, including retinal vein occlusion (HR 1.58) and glaucoma (HR 1.40).

This systematic review and meta-analysis of 7 studies (187 participants, 236 eyes) found that oral acetazolamide achieved visual acuity improvement in 53% and anatomical improvement in 55% of patients with uveitic macular edema.

The OcuPan assay, a highly multiplexed panel detecting 46 ocular pathogens, demonstrated 50.9% sensitivity and 100% specificity for diagnosing infectious uveitis, with excellent agreement (93.5%) compared to PCR testing.

A multi-modal approach involving aggressive immunosuppression, periocular steroid injections to elevate IOP, and intentional aphakia after lens aspiration achieved successful visual outcomes in two young patients with uveitic cataracts and chronic hypotony.

Diplopia occurs in 38.9% of patients after I-125 plaque brachytherapy for uveal melanoma but typically resolves spontaneously within 6 months, while strabismus develops in 7.2% of cases.

Based on the title alone, this study emphasizes that enucleation remains a critical intervention for eyes with high-risk retinoblastoma features to ensure patient survival.

Aqueous humor L-lactate levels were significantly elevated in uveal melanoma eyes compared to controls and correlated with tumor mitotic activity, suggesting potential utility as a diagnostic biomarker.

This multicenter study of 292 retinoblastoma patients with post-laminar optic nerve invasion demonstrates that adjuvant chemotherapy after primary enucleation significantly reduces orbital recurrence, metastasis, and death compared to no adjuvant therapy.

This meta-analysis of 1,583 eyes found that intravitreal silicone oil contamination occurs in 57.56% of eyes following intravitreal injections, with floaters developing in 27.85% of cases.

A large population-based study of 44,571 patients found no significant difference in kidney injury risk between intravitreal aflibercept and ranibizumab despite aflibercept's greater systemic VEGF suppression.